2-heteroarylamino-pyrimidine derivatives as kinase inhibitors

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United States of America Patent

PATENT NO 8288540
APP PUB NO 20110053952A1
SERIAL NO

12673948

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Abstract

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The invention provides compounds of Formula (I) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, Fms, KDR, c-raf or b-raf kinases.

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Patent Owner(s)

Patent OwnerAddress
IRM LLCHURST HOLME 12 TROTT ROAD HAMILTON HM 11

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chianelli, Donatella San Diego, US 27 301
Li, Xiaolin San Diego, US 141 1247
Liu, Xiaodong San Diego, US 213 1292
Loren, Jon San Diego, US 22 379
Molteni, Valentina San Diego, US 56 467
Nabakka, Juliet San Diego, US 27 280

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