Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
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United States of America Patent
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Oct 16, 2012
Grant Date -
May 5, 2011
app pub date -
Jul 30, 2010
filing date -
Jul 31, 2009
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Abstract
Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
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