Method of preparing clarithromycin
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United States of America Patent
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Oct 16, 2012
Grant Date -
Nov 4, 2010
app pub date -
Apr 30, 2010
filing date -
Apr 30, 2009
priority date (Note) -
Expired
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Abstract
This invention discloses a method of manufacturing clarithromycin, where an erythromycin A 9-oxime thiocyanate salt is used directly to perform an etherification reaction, and then successively silanizattion, methylattion and hydrolysis reactions are sequentially conducted. It is a new process with simple process with a high yield, low cost, less pollution, high quality and is suitable for commercial manufacturing.
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