Pyrimidopyrimidoindazole derivative

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United States of America Patent

PATENT NO 8288396
APP PUB NO 20120134955A1
SERIAL NO

13202773

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a): R1 means a —(C═O)aOb(C1-C6)alkyl group, a —(C═O)aOb(C2-C6)alkenyl group, a —(C═O)aOb(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; R2 and R3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a —(C═O)aOb(C1-C6)alkyl group or a group of —(C═O)aN(R1e)R2e; R4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.

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Patent Owner(s)

Patent OwnerAddress
MSD K KCHIYODA-KU TOKYO 102-8667

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goto, Yasuhiro Tachikawa, JP 81 1070
Niiyama, Kenji Tsuchiura, JP 18 218
Sunami, Satoshi Toride, JP 11 75
Takahashi, Keiji Yachiyo, JP 96 1024

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