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Abstract

A rapid, safe method for predicting sepsis, or a condition similar to sepsis, in a mammal is disclosed, which comprises the following steps:

I) isolating RNA from a biological sample of a mammal;ii) labeling the isolated RNA of step I) with a detectable marker;iii) hybridizing the labeled isolated RNA of step ii) with at least one DNA of genes Seq.-ID 1 to Seq.-ID 6705 (Table 1), which is spotted onto a microarray and which is a sepsis-specific gene or gene fragment, under the reaction conditions for hybridizations;iv) quantitatively recording labeling signals of the hybridized RNA of step iii) in an expression profile;v) comparing the expression profile of step iv) with a control sample with respect to a stronger or weaker expression of genes or gene fragments which are specific for sepsis; andvi) combining the expression profile of step v) with protein- and metabolite patterns of the biological sample.

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First Claim