Tuberculosis vaccine
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United States of America Patent
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Oct 16, 2012
Grant Date -
May 27, 2010
app pub date -
Mar 14, 2007
filing date -
Mar 24, 2006
priority date (Note) -
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Abstract
An isolated microorganism belonging to the genus Mycobacterium, having one or both of an inactivated gene Rv0757 that confers a PhoP− phenotype and an inactivated second gene which prevents the production of DIM (DIM− phenotype). Methods of making the microorganism, related pharmaceutical formulations and vaccines are also provided, as are related methods of treatment and vaccination. The pharmaceutical formulation may also serve as a vector or adjuvant.
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