hyperexpressing recombinant cholera toxin B subunit showing dual immunogenicity
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United States of America Patent
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Oct 16, 2012
Grant Date -
May 27, 2010
app pub date -
Apr 24, 2008
filing date -
Apr 24, 2007
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Abstract
Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the delivery of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.
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