T cell receptor mutants
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United States of America Patent
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Oct 9, 2012
Grant Date -
Feb 2, 2012
app pub date -
Aug 4, 2010
filing date -
Jul 28, 2010
priority date (Note) -
Expired
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Abstract
A T cell receptor (TCR) having the property of binding to EVDPIGHLY HLA-A1 complex and comprising a specified wild type TCR which has specific mutations in the TCR alpha variable domain and/or the TCR beta variable domain to increase affinity. Such TCRs are useful for adoptive therapy.
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