DPH2 gene deletion mutant and uses thereof
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United States of America Patent
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Oct 9, 2012
Grant Date -
Nov 5, 2009
app pub date -
Jun 18, 2007
filing date -
Jun 16, 2006
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Abstract
Diphtheria and Pseudomonas infections are very common worldwide. The toxins involved in the pathogenesis of those diseases act by inactivating the elongation factor-2 (EF-2), therefore blocking protein synthesis and leading to cell death. Diphthamide formation on EF-2 is a prerequisite step in the inactivation of EF-2, and Dph proteins have been identified as modulating this process. The present application concerns Dph2 deletion mutant genes and proteins and their uses in vitro and in vivo.
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