System and method for increasing polymer/nanopore interactions
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United States of America Patent
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Oct 9, 2012
Grant Date -
Jul 7, 2011
app pub date -
Jun 18, 2009
filing date -
Jun 18, 2008
priority date (Note) -
Expired
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Abstract
An electrolytic system includes an analyte chamber having an access port for introducing a sample containing a molecules of interest, such as DNA. Electrodes create an electric field along a length of the analyte chamber to drive molecules toward an interaction region containing a nanopore, thereby increasing the arrival rate of molecules at the nanopore. Additional electrodes may be utilized to create an electric field through the nanopore to drive a molecule into the nanopore. A current sensor may be utilized to count, discriminate or characterize the molecules as they interact with the nanopore. Advantageously, system can be utilized for unamplified DNA sequencing.
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