Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
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United States of America Patent
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Oct 9, 2012
Grant Date -
Jun 3, 2010
app pub date -
Mar 9, 2009
filing date -
Nov 28, 2008
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Abstract
The present invention provides an avian influenza vaccine containing a peptide-bound liposome wherein; the peptide contains:
- (1) an amino acid sequence shown by any one of SEQ ID NO:1 to 9, or(2) an amino acid sequence shown by any one of SEQ ID NO:1 to 9wherein one or two amino acids are substituted,has a length of 9 to 11 amino acids, andis capable of inducing HLA-restricted cytotoxic T lymphocytes;wherein the liposome contains a phospholipid having an acyl group with 14 to 24 carbon atoms and one unsaturated bond or a hydrocarbon group with 14 to 24 carbon atoms and one unsaturated bond, and a liposome stabilizer; andwherein the peptide is bound to the surface of the liposome.
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