Process and intermediate compounds useful in the preparation of statins
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United States of America Patent
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Oct 2, 2012
Grant Date -
Dec 17, 2009
app pub date -
Nov 28, 2005
filing date -
Dec 16, 2004
priority date (Note) -
Expired
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Abstract
There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.
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