Dimeric high affinity EGFR constructs and uses thereof
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United States of America Patent
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Oct 2, 2012
Grant Date -
Apr 22, 2010
app pub date -
Dec 20, 2007
filing date -
Dec 21, 2006
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Abstract
Polypeptides comprising EGFR extracellular domains I-III capable of forming dimeric EGF-binding proteins are provided. The dimeric construct of the invention is useful in applications where high affinity EGF binding is desired and can be used to select agents capable of binding to native EGFR in the presence of EGF.
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