Method of treating ischemia/reperfusion injury with nitroxyl donors
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United States of America Patent
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Sep 18, 2012
Grant Date -
Oct 1, 2009
app pub date -
Dec 30, 2008
filing date -
Jun 14, 2002
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Abstract
Nitroxyl donating compounds are administered prior to the onset of ischemia for the prevention and/or reduction of ischemia/reperfusion injury in subjects at risk for ischemia. Nitroxyl donors also are administered to organs to be transplanted for the prevention and/or reduction of ischemia/reperfusion injury upon reperfusion in a recipient. Nitroxyl donors include any nitroxyl donating compound. In particular cases the nitroxyl donor is a nitroxyl-donating diazeniumdiolate, such as Angeli's salt or IPA/NO.
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