Antibodies against CSF-1R
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United States of America Patent
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Sep 11, 2012
Grant Date -
Oct 6, 2011
app pub date -
Mar 28, 2011
filing date -
Apr 1, 2010
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Abstract
The invention provides a human antibody that binds human CSF-1R with high affinity. Antibodies of the present invention have significant advantages over the antibodies known in the art by being multifunctional: inhibiting signaling of CSF-1R, internalizing and inducing CSF-1R degradation and stimulating ADCC in cell including tumors, macrophages and monocytes. They are also shown to be effective in treating leukemia, breast, endometrial and prostate cancer alone or in combination with docetaxel, paclitaxel, Herceptin® or doxorubicin.
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