Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof
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United States of America Patent
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Sep 11, 2012
Grant Date -
May 17, 2012
app pub date -
Dec 16, 2011
filing date -
Oct 16, 2003
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Expired
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Abstract
The present invention is directed to an antibody or fragments thereof that are specific for a fibroblast growth factor receptor (FGFR)-1(IIIb), FGFR-1(IIIc), and/or FGFR-4. Also, provided herein, are vectors and host cells comprising the nucleic acids encoding those antibodies. The present invention further provides methods of antagonizing FGFR-1 or FGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
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