Multimeric VLA-4 antagonists comprising polymer moieties

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United States of America Patent

PATENT NO 8263063
APP PUB NO 20110002876A1
SERIAL NO

12877496

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Abstract

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Disclosed are conjugates exhibiting VLA-4 antagonistic properties. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. The conjugates of this invention are characterized as containing more than one VLA-4 inhibiting compound covalently attached to a bio-compatible polymer, such as polyethylene glycol. Conjugates of the invention are defined by formula I,

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Patent Owner(s)

Patent OwnerAddress
ELAN PHARMACEUTICALS INC800 GATEWAY BOULEVARD SOUTH SAN FRANCISCO CA 94080

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Konradi, Andrei W Burlingame, US 101 764
Pleiss, Michael A Sunnyvale, US 124 945
Semko, Christopher M Fremont, US 40 332
Smith, Jenifer L South San Francisco, US 15 163
Yednock, Theodore Forest Knolls, US 28 673

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