Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide
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United States of America Patent
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Aug 28, 2012
Grant Date -
Feb 11, 2010
app pub date -
Dec 21, 2007
filing date -
Dec 29, 2006
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Expired
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Abstract
The present invention relates to nucleotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof that are modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences.
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