Methods of inhibiting alpha-4-dependent interactions with VCAM-1 with anti-VLA-4 antibodies
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United States of America Patent
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Aug 21, 2012
Grant Date -
Apr 1, 2010
app pub date -
Jul 17, 2008
filing date -
Jan 25, 1994
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Expired
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Abstract
The invention provides methods of treatment using humanized immunoglobulins that specifically bind to alpha-4 integrin. The methods are useful for treatment of asthma, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, transplant rejection, graft versus host disease, tumor metastasis, nephritis, atopic dermatitis, psoriasis, myocardial ischemia, and acute leukocyte mediated lung injury.
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