Vascular therapeutics
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United States of America Patent
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Aug 14, 2012
Grant Date -
Jun 2, 2005
app pub date -
Aug 20, 2004
filing date -
Feb 27, 2002
priority date (Note) -
Expired
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Abstract
The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and/or solid tumor growth in a subject The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.
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