Modified polypeptides stabilized in a desired conformation and methods for producing same
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United States of America Patent
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Aug 14, 2012
Grant Date -
Dec 15, 2011
app pub date -
Jun 22, 2011
filing date -
Sep 1, 2000
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Abstract
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where crysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation.
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