Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use
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United States of America Patent
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Jul 31, 2012
Grant Date -
Dec 10, 2009
app pub date -
Oct 2, 2007
filing date -
Oct 2, 2006
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Expired
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Abstract
The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
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