High affinity Melan-A T cell receptors

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United States of America Patent

PATENT NO 8217144
APP PUB NO 20080292549A1
SERIAL NO

11915766

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides TCRs having an affinity (KD) of less than or equal to 3 μM, and/or an off-rate (koff) of 1×10−3 S−1 or slower, for the AAGIGILTV-HLA-A*0201 complex. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting cancer cells presenting that complex.

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Patent Owner(s)

Patent OwnerAddress
IMMUNOCORE LIMITEDABINGDON OXFORDSHIRE OX14 4RY
ADAPTIMMUNE LIMITED60 JUBILEE AVE MILTON PARK ABINGDON OXFORDSHIRE OX14 4RX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jakobsen, Bent Karsten Abingdon, GB 66 654
Liddy, Nathaniel Ross Abingdon, GB 17 118

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