Liquid phase peptide synthesis of KL-4 pulmonary surfactant
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United States of America Patent
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Jul 10, 2012
Grant Date -
Oct 15, 2009
app pub date -
Sep 30, 2008
filing date -
Jul 17, 1996
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Abstract
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.
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