Polyene diester antibiotics
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United States of America Patent
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Jul 10, 2012
Grant Date -
Aug 19, 2010
app pub date -
Jul 30, 2007
filing date -
Jul 30, 2007
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Expired
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Abstract
The present invention discloses a new polyene diester and its preparation. This polyene diester has a structure of Formula 1, which is used as prodrugs by introducing diester group to polyene antibiotics, and these prodrugs exhibit antifungal or antiviral activities through releasing parent polyenes by esterase in vivo. The new derivatives have good antimicrobial activity and better safety. These new derivatives are useful for the antifungal and antiviral treatment. PA-COOR Formula 1
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