Paramyxovirus vector encoding angiogenesis gene and use thereof
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United States of America Patent
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Jul 3, 2012
Grant Date -
Sep 1, 2011
app pub date -
Mar 16, 2011
filing date -
Nov 27, 2000
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Abstract
The present invention provides Paramyxovirus vectors encoding angiogenic genes and use of the same. The use of Paramyxovirus vectors enables effective transfer of angiogenic genes into individual tissues. FGF2 gene transferred into ischemic tissues in vivo induces expression of angiogenic genes without causing edema, and prevents necrosis due to ischemia. The vectors of the present invention are suitable for gene therapy targeted to ischemic tissues.
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