High capacity non-viral vectors

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United States of America Patent

PATENT NO 8202544
APP PUB NO 20100113695A1
SERIAL NO

12562184

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Abstract

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Non-viral vectors for delivering agents to a site within the body of an animal comprise a biocompatible nanoparticle conjugated to an avidin/biotin complex and a water soluble linear polymer comprising multiple binding sites. The agents to be delivered are conjugated to each of the multiple binding sites, thereby increasing the loading capacity of the system. Where the agents comprise siRNA, each biotin/avidin complex may carry greater than four siRNA. The biocompatible nanoparticle may also comprise a fluorescent dye for in vivo imaging.

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Patent Owner(s)

Patent OwnerAddress
BRUKER BIOSPIN CORPORATION15 FORTUNE DRIVE BILLERICA MA 01821

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ji, Tao Hamden, US 42 88
McLaughlin, William E Guilford, US 21 158
Papineni, Rao Branford, US 11 54

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