Compositions and methods with enhanced therapeutic activity
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United States of America Patent
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Jun 12, 2012
Grant Date -
Dec 2, 2004
app pub date -
Mar 1, 2004
filing date -
Feb 28, 2003
priority date (Note) -
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Abstract
Novel quinone and catechol compositions, compositions containing prodrugs of quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. The disclosure particularly relates to the discovery of dual activity agents capable of generating both a vascular targeting effect and direct tumor cell cytotoxicity in order to achieve an enhanced anti-tumor response in a patient.
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