Recombinant platelet collagen receptor glycoprotein VI and its pharmaceutical use
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United States of America Patent
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Jun 12, 2012
Grant Date -
Jul 26, 2007
app pub date -
Mar 21, 2007
filing date -
May 7, 1999
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Abstract
The invention relates to Glycoprotein VI (GPVI), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the use of GPVI, preferably recombinant GPVI, in the treatment of disorders and pathological events correlated directly or indirectly to blood coagulation disorders such as thrombotic and cardiovascular diseases. The extracellular recombinant protein can also be used for establishing screening assays to find potential inhibitors of the membrane bound GPVI in order to inhibit binding of thrombocytes and platelets, respectively, to collagen. Changes in GPIV can be used to monitor platelet age and exposure to thrombotic and cardiovascular diseases.
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