Creation of artificial internal ribosome entry site (IRES) elements
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United States of America Patent
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Jun 5, 2012
Grant Date -
Mar 17, 2005
app pub date -
Sep 3, 2002
filing date -
Sep 4, 2001
priority date (Note) -
Expired
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Abstract
A method of producing a nucleic acid sequence having an adenine-rich nucleic acid block of at least 25 nucleotides in length is provided. The nucleic acid sequence that is produced is capable of initiating translation at an internal ribosome entry site (IRES) and the adenine-rich nucleic acid block comprises from 40 to 100 mol-% adenine.
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