High activity growth factor mutants
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United States of America Patent
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May 29, 2012
Grant Date -
Dec 25, 2008
app pub date -
Nov 17, 2006
filing date -
Nov 18, 2005
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Abstract
The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction.
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