Extended release oral dosage composition
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United States of America Patent
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May 29, 2012
Grant Date -
Jan 28, 2010
app pub date -
Oct 2, 2009
filing date -
Dec 20, 1999
priority date (Note) -
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Abstract
A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and (b) a sustained release second layer comprising an effective amount of a nasal decongestant, e.g. pseudoephedrine sulfate and a pharmaceutically acceptable sustained release agent wherein the composition contains less than about 2% of desloratadine decomposition products is disclosed. A solid composition comprising an anti-allergic effective amount of desloratadine and at least one, and preferably two pharmaceutically acceptable antioxidants is also disclosed.
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