Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof
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United States of America Patent
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May 22, 2012
Grant Date -
Aug 5, 2010
app pub date -
Feb 26, 2008
filing date -
Mar 6, 2007
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Expired
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Abstract
PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
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