Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms
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United States of America Patent
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May 22, 2012
Grant Date -
Jul 5, 2007
app pub date -
Jan 17, 2005
filing date -
Jan 30, 2004
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Abstract
The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient (“API”), a pharmaceutically acceptable cyclodextrin and a pharmaceutically acceptable preservative. The invention is also directed to pharmaceutical compositions of the compounds of Formula (I) wherein R2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl and a pharmaceutically acceptable cyclodextrin and preservative. Formula (I): In particular, the invention is directed to pharmaceutical compositions of the compound of Formula 1a, and a pharmaceutically acceptable cyclodextrin and a preservative.
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