C-terminally truncated interferon alpha variants

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United States of America Patent

PATENT NO 8182803
APP PUB NO 20110250177A1
SERIAL NO

13105571

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Abstract

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The present invention provides biologically active variants of human α-2b-interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length human α-2b-interferon. It is the novel finding of the present invention that these truncated variants have the biological activity of full-length human α-2b-interferon. The invention encompasses these biologically active variant α-interferons, as well as polynucleotides encoding these interferons. Expression cassettes comprising these polynucleotides and host cells comprising the expression cassettes are also provided. The invention also provides compositions comprising variant α-interferon polypeptides and a pharmaceutically acceptable carrier.

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Patent Owner(s)

Patent OwnerAddress
SYNTHON BIOPHARMACEUTICALS B V6545 CM NIJMEGEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cox, Kevin Raleigh, US 16 541
Dickey, Lynn Cary, US 10 66
Gasdaska, John Chapel Hill, US 7 65

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