Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use

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United States of America Patent

PATENT NO 8178527
APP PUB NO 20100022528A1
SERIAL NO

12443906

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Abstract

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Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

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Patent Owner(s)

Patent OwnerAddress
ERIMOS PHARMACEUTICALS LLC9600 BELLAIRE BOULEVARD SUITE 228 HOUSTON TX 77036

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Qingqi Chapel Hill, US 14 68
Heller, Jonathan Daniel San Francisco, US 10 99
Lopez, Rocio Alejandra Raleigh, US 10 99
Morris, Amanda Jean Graham, US 7 29

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