Methods of using an alpha-1-adrenergic receptor having altered ligand affinity
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United States of America Patent
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May 8, 2012
Grant Date -
May 13, 2010
app pub date -
May 22, 2008
filing date -
May 23, 2007
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Expired
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Abstract
A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has been expressed. This makes it possible to provide a technique for analyzing the function of many putative GPCRs whose entities have not been clarified.
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