Nucleic acids encoding novel chimeric C15/prM/E dengue virus immunogens prepared by DNA shuffling
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United States of America Patent
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May 1, 2012
Grant Date -
Dec 17, 2009
app pub date -
Aug 30, 2007
filing date -
Feb 26, 2002
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Abstract
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability to induce an immune response to flaviviruses. The polypeptides and polynucleotides of the invention are useful in methods of inducing immune response against flaviviruses, including dengue viruses. Compositions and methods for utilizing polynucleotides and polypeptides of the invention are also provided.
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