Mediators of hedgehog signaling pathways, compositions and uses related thereto
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United States of America Patent
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May 1, 2012
Grant Date -
Dec 16, 2010
app pub date -
Aug 2, 2010
filing date -
Nov 3, 2004
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Abstract
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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