Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
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United States of America Patent
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Apr 17, 2012
Grant Date -
Dec 18, 2008
app pub date -
Aug 3, 2006
filing date -
Aug 5, 2005
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Abstract
This invention relates to compounds comprising one or more therapeutic and/or diagnostic moieties and one or more functional moieties linked together via one or more triazole-containing linkers and to their intermediates and methods of their preparation. The triazole-containing linker may optionally contain one or more conditionally-cleavable or conditionally-transformable moieties and one or more spacer systems in between said moiety/moieties and the one or more therapeutic and/or diagnostic moieties.
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