Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells
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United States of America Patent
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Apr 17, 2012
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Apr 22, 2010
app pub date -
Feb 27, 2008
filing date -
Feb 27, 2007
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Abstract
The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells.
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