Cell death-inducing agent
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United States of America Patent
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Apr 17, 2012
Grant Date -
Dec 7, 2006
app pub date -
Oct 10, 2003
filing date -
Oct 11, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
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