Modulation of toll-like receptor 3 expression by antisense oligonucleotides
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United States of America Patent
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Apr 10, 2012
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app pub date -
Aug 4, 2009
filing date -
Aug 4, 2008
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Abstract
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR3. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR3 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR3 expression and for prevention or treatment of diseases wherein modulation of TLR3 expression would be beneficial are provided.
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