Azithromycin-containing aqueous pharmaceutical composition and a method for the preparation of the same
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United States of America Patent
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Apr 10, 2012
Grant Date -
Apr 19, 2007
app pub date -
Dec 20, 2006
filing date -
Jul 2, 2004
priority date (Note) -
Expired
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Abstract
The invention provides an azithromycin-containing aqueous pharmaceutical composition, which comprises at least one member selected from the group consisting of azithromycin, and pharmaceutically acceptable salts thereof, and at least one member selected from the group consisting of monoethanolamine, diethanolamine, triethanolamine, and pharmaceutically acceptable salts thereof, and which does not comprise boric acid or pharmaceutically acceptable salts thereof, and a method for the preparation of the composition, wherein an azithromycin-containing liquid is maintained at pH of 4.0 or higher throughout the method for the preparation. The composition has good heat and storage stability.
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