Scaleable manufacturing process for cysteine endoprotease B, isoform 2
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United States of America Patent
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Apr 3, 2012
Grant Date -
Aug 5, 2010
app pub date -
Mar 14, 2008
filing date -
Mar 16, 2007
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Expired
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Abstract
Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.
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