Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs

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United States of America Patent

PATENT NO 8148102
APP PUB NO 20100261878A1
SERIAL NO

12526202

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Abstract

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Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analogs of these molecules and methods of using these FK228 analogs. Chromobacterium and Burkholderia gene inactivation mutants are provided. Methods of forming a disulfide bond in a chemical are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
UWM RESEARCH FOUNDATION INC1440 EAST NORTH AVENUE MILWAUKEE WI 53202

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Yi-Qiang Grafton, US 5 4

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