Agents capable of downregulating an MSF-A dependent HIF-1α and use thereof in cancer treatment
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United States of America Patent
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Mar 27, 2012
Grant Date -
Apr 16, 2009
app pub date -
Jul 12, 2005
filing date -
Jul 12, 2004
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Abstract
Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or dissociating the MSF-A-HIF-1alpha protein complex, and methods of determining the prognosis of an individual having cancer by identifying the presence or absence of such a protein complex.
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