Modified beta-glucosidases with improved stability
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United States of America Patent
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Mar 27, 2012
Grant Date -
Apr 15, 2010
app pub date -
Aug 31, 2009
filing date -
Aug 29, 2008
priority date (Note) -
Expired
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Abstract
Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improved stability at low pH, low pH and high aeration, low pH and high agitation, or low pH and elevated temperature. Also provided are genetic constructs comprising nucleotide sequences encoding for modified beta-glucosidase enzymes, methods for the production of modified beta-glucosidase enzymes from host strains and the use of the modified beta-glucosidase enzymes in the hydrolysis of cellulose.
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