11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
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United States of America Patent
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Mar 20, 2012
Grant Date -
Apr 23, 2009
app pub date -
Oct 12, 2005
filing date -
Oct 12, 2004
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Expired
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Abstract
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11 β-hydroxy-Steroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.
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