Methods of use of the TACI/TACI-L interaction
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United States of America Patent
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Mar 13, 2012
Grant Date -
Aug 5, 2010
app pub date -
Nov 6, 2009
filing date -
Apr 30, 1999
priority date (Note) -
Expired
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Abstract
The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to inhibit graft vs. host rejections is further disclosed.
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